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[Feb.14.2014]   
Explore our new Nematode Tissue Transcriptomes section!

[Jan.31.2014]   
NemaPath has been updated and expanded!

[Jan.21.2014]   
The genome of the human, blood-feeding hookworm Necator americanus has been decoded!





Our Mission:

Parasitic roundworms (nematodes) of humans, livestock and other animals cause diseases of major socio-economic importance globally. They have a major, long-term impact (directly and indirectly) on human health and cause substantial suffering, particularly in children. The World Health Organization (WHO) estimates that 2.9 billion people are infected with nematodes. Furthermore, the current financial losses caused by parasites to agriculture worldwide (domesticated animals and crops) have a major impact on farm profitability and exacerbate the global food shortage.


Methods available for the control of the parasitic nematode infections are mainly based on chemical treatment (anthelmintics), non-chemical management practices, immune modulation and biological control. However, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic nematodes hampered what use to be effective and long-lasting control strategies. Moreover, the use of such drugs poses major risks of residue problems in meat, milk and the environment.



  
Therefore, the challenges to improve control of parasitic nematode infections are multi-fold and no single category of information will meet them all. However, new information, such as nematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed at developing improvements. Our MISSION is through integrated approaches to accelerate progress towards developing more efficient and sustainable parasitic nematode control programs.

Citation:

To cite Nematode.net please use:

Martin J., Abubucker S., Heizer E., Taylor C.M. and Mitreva M. (2011) Nematode.net update 2011: addition of data sets and tools featuring next-generation sequencing data Nucleic Acids Research first published online December 1, 2011 doi:10.1093/nar/gkr1194

Project Status:      Status of nematode genome sequencing projects at The Genome Institute.

Species Material
Acquisition
Sequencing Assembly Assembly
Evaluation
Annotation Annotation
Evaluation
Published
Ancylostoma caninum
Ancylostoma ceylanicum
Ancylostoma duodenale
Ascaris suum
Cooperia oncophora
Dictyocaulus viviparus
Globodera pallida
Haemonchus contortus
Necator americanus
Nematodirus battus
Nippostrongylus brasiliensis
Oesophagostomum dentatum
Onchocerca volvulus
Ostertagia ostertagi
Strongyloides ratti
Teladorsagia circumcincta
Trichinella spiralis
Trichuris muris
Trichuris suis


Completed genomes:

Published Genomes Source BioProject id NCBI taxon id Publication link
Ascaris suum University of Melbourne PRJNA80881 6253 Ascaris suum draft genome
Ascaris suum University of Colorado/WUGI PRJNA62057 6253 Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles
Brugia malayi University of Pittsburgh PRJNA10729 6279 Draft Genome of the Filarial Nematode Parasite Brugia malayi
Caenorhabditis briggsae WTSI PRJNA10731 6238 The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
Caenorhabditis elegans The C. elegans Sequencing Consortium PRJNA158 6239 Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology
Haemonchus contortus WTSI PRJEB506 6289 The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery
Haemonchus contortus University of Melbourne PRJNA205202 6289 The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus
Loa loa Broad Institute PRJNA60051 7209 Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
Meloidogyne hapla NCSU PRJNA29083 6305 Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism
Meloidogyne incognita INRA PRJEA28837 6306 Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita.
Necator americanus TGI PRJNA72135 51031 Genome of the human hookworm Necator americanus.
Pristionchus pacificus Max Planck Institute/TGI PRJNA12644 54126 The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism.
Trichinella spiralis TGI PRJNA12603 6334 The draft genome of the parasitic nematode Trichinella spiralis

Please note that our lab is a sequencing and analysis facility; we are not clinicians, and as such we are not qualified to provide medical advice regarding parasitic nematode afflictions. If you are in need of such assistance, please instead contact a qualified physician, preferably one with a specialty in parasitic diseases.


 
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