Curriculum Vitae (October, 2004)
James P. McCarter, M.D., Ph.D.
ADDRESS
Divergence Inc.
893 North Warson Road
St. Louis, MO 63141 USA
Phone 314-812-8093, Fax 314-812-8080
mccarter@divergence.com or mccarter@genetics.wustl.edu
PROFESSIONAL EXPERIENCE
Divergence Inc., St. Louis, Missouri
Founder, President, and Chief Scientific Officer, 1998 - Present
Initiated and currently lead scientific discovery for biotechnology start-up firm Divergence, a pioneer in the development of safe and effective nematode control. Created company's business plan and scientific strategy for genome-data mining and RNA interference target validation. Recruited 20 member team, scientific advisory board, general and legal counsels. Oversee projects in nematicide and anthelmintic development, transgenic plant development, and vaccine target identification. Company accomplishments include - establishment of collaboration in nematode resistant soy with Monsanto Company, discovery of potent nematicidal chemicals with excellent environmental safety profiles and success in greenhouse trials, >30 patent applications and issued patents on methods for parasite control, raising $9 million in equity funding, receipt of 11 grants from NIH, NSF, USDA, EPA, and the National Corn Growers Association, 2004 Danforth Distinguished Service Award, 2002 Missouri Biotechnology Association Award for Excellence in Entrepreneurship, 2002 St. Louis Technology Award, 2002 & 2003 St. Louis Technology Top 50 Company.
Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri
Adjunct Instructor in Genetics, 2003 - Present
Research Instructor in Genetics, 2002 - 2003
Post-Doctoral Fellow and Group Leader, Parasitic Nematode Genome Projects, 1998 - 2002
Initiated and led the world's largest effort aimed at sequencing human, animal, and plant parasitic nematodes. Generated over 250,000 Expressed Sequence Tags (ESTs) from 28 nematode species. Funding provided by the National Institute of Allergy and Infectious Disease at NIH., NSF, the Helen Hay Whitney Foundation, Merck Inc., the Max Planck Institute, and the British Medical Research Council. Post-doctoral Advisor: Robert Waterston, Chairman of Genetics, GSC Director
EDUCATION
M.D. and Ph.D., Medical Scientist Training Program, 1998, Washington University School of Medicine, St. Louis, Missouri
Ph.D., Dept. of Genetics, Program in Developmental Biology, Thesis; The Regulation of Oocyte Maturation and Ovulation in C. elegans. Advisor; Tim Schedl, Teaching; Medical Genetics.
A.B., Magna Cum Laude in Biology, 1989, Princeton University, Princeton, New Jersey
Thesis; Adh-Dup Locus Nucleotide Polymorphism in Drosophila simulans, Advisor; Martin Kreitman, Chair of Undergraduate Biology Committee, Varsity Heavyweight Crew
RESEARCH INTERESTSParasitology, C. elegans Genetics, Applications of Genomics to the Development of Anthelmintic Drugs for Humans and Animals, Crop Nematicides, and Plants with Nematode Resistance
HONORS AND AWARDS
Danforth Distinguished Service Award, With Derek Rapp and Divergence, Inc., 2004
Alumni Bridges Award, Washington University Graduate and Professional Council, 2004
Innovation Award, Academy of Science of St. Louis, 2003
Henry Crown Fellow of the Aspen Institute, 2002 - 2004
Who's Who in St. Louis Biotechnology, 2003
Who's Who in America, 2002- ; Who's Who in Science and Engineering, 2003-
St. Louis Business Journal's 40-Under-40 List of Business Leaders, 2002
Merck Postdoctoral Fellowship of the Helen Hay Whitney Foundation, 1999 - 2002
NIH National Human Genome Research Institute Post-Doctoral Fellowship, 1998 - '99
Spencer T. and Ann W. Olin Pre-doctoral Fellowship, Washington Univ., 1997 - '98
Olin Cup Entrepreneur, Runner-up MBA Team, Washington Univ. School of Business Hatchery, 1998
Graduate Student Representative to the Washington Univ. Board of Trustees, 1996 - '97
Victor Hamburger Academic Prize in Developmental Biology, Washington Univ., 1996
NIH Medical Scientist Training Program Pre-doctoral Fellowship, Washington Univ., 1990 - '92
Cannon Memorial Award for Best Senior Thesis Presentation in Biology, Princeton University, 1989
Elected to Membership in Sigma Xi, Princeton University, 1989
Bausch and Lomb Science Award, Sycamore High School, Sycamore IL, 1985
PRIOR WORK EXPERIENCE AND TRAINING
Researcher; Molecular Evolution, Princeton University, Princeton NJ, 1990
Course Assistant; Neurobiology, Marine Biological Lab, Woods Hole MA, 1989
Researcher; Growth Hormone Biochemistry, Northwestern University, Chicago IL, 1988
Counselor and Instructor; Camp Lincoln, Brainerd MN, 1987
Lab and Field Technician; Corn Genetics, DeKalb Corporation, DeKalb IL, 1985 & 1982
PUBLICATIONS
McCarter, J. P. 2004. "Genomic Filtering, an Approach to Discovering Novel Antiparasitics," Trends in Parasitology , 20:462-468.
Mitreva, M., D. P. Jasmer, J. Appleton, J. Martin, M. Dante, T. Wylie, S. W. Clifton, and R. H. Waterston, and J. P., McCarter. 2004. " Gene discovery in the adenophorean nematode Trichinella spiralis : an analysis of transcription from three life cycle stages," Molecular and Biochemical Parasitology , 137:277-291.
Jasmer, D. P., M. D. Mitreva, J. P. McCarter. 2004. "mRNA Sequences for Haemonchus contortus intestinal cathepsin B-like cysteine proteases display an extreme in abundance and diversity among mammalian parasitic nematodes," Molecular and Biochemical Parasitology , 137:297-305.
Mitreva, M.D., A. A. Elling, M. Dante, A. P. Kloek, A. Kalyanaraman, S. Aluru, S. W. Clifton, D. M. Bird, T. J. Baum, and J. P. McCarter. 2004. "A Survey of SL-1 spliced transcripts from the root-lesion nematode Pratylenchus penetrans ," Molecular Genetics and Genomics , 272:138-148.
Behm, C. A., M. M. Bendig, J. P. McCarter, A. E. Sluder. 2004. "WHO/TDR Scientific Working Group on 'RNA Interference as a Means of Identifying Drug Targets for Filariasis' Report, World Health Organization Tropical Disease Research Publication, www.who.int/tdr/publications/publications/rnai.htm
Mitreva, M. D., J. P., McCarter, J. Martin, M. Dante, T. Wylie, B. Chiapelli, D. Pape, S. W. Clifton, T. B. Nutman, and R. H. Waterston. 2004. "Comparative Genomics of Gene Expression in the Parasitic and Free-living Nematodes Strongyloides stercoralis and Caenorhabditis elegans ," Genome Research, 14:209-220. (joint 1 st author)
Wylie, T., J.C. Martin, M. Dante, M. D. Mitreva, S. W. Clifton, A. Chinwalla, R. H. Waterston, R. K. Wilson, and J. P. McCarter. 2004. "Nematode.net: a Tool for Navigating Sequences from Parasitic and Free-living Nematodes," Nucleic Acids Research , 32:D423-D426.
Parkinson, J., M. Mitreva, C. Whitton, M. Thomson, J. Daub, J. Martin, N. Hall, B. Barrell, R. H. Waterston, J. P. McCarter, and M. Blaxter. 2004. "A Transcriptomic Analysis of the Phylum Nematoda," Nature Genetics , In Press.
Behm, C. A., M. M. Bendig, J. P. McCarter, A. E. Sluder. 2004. "RNA Interference-based Discovery and Validation of New Drug Targets in Filarial Nematodes," Trends in Parasitology, In Press .
Mitreva, M., J. Appleton, J. P. McCarter, and D. P. Jasmer. 2004. "Expressed Sequence Tags From Life Cycle Stages of Trichinella spiralis : Application to Biology and Parasite Control, " Veterinary Parasitology , In Press .
Mitreva, M., P. Arasu, J. Hawdon, J. Martin, M. Dante, T. Wylie, J. Xu, J. E. Stajich, V. Kapulkin, S. W. Clifton, R. H. Waterston, R. Wilson, and J. P. McCarter. 2004. "Investigating Hookworm Genomes by Comparative Analysis of Two Ancylostoma Species," Submitted .
Vanholme, B., M. Mitreva, W. V. Criekinge, M. Logghe, J. P. McCarter, and G. Gheysen. 2004. "Detection of Proteins Secreted by the Plant-parasitic Nematode Heterodera schachtii Based on Expressed Sequence Tags Analysis," In Preparation .
McCarter, J. P., M. Mitreva, S. W. Clifton, D. M. Bird and R. H. Waterston. 2003. "Nematode Gene Sequences: Update for December, 2003," Journal of Nematology , 35:465-469.
Parkinson, J., M. Mitreva, N. Hall, M. Blaxter, and J. P. McCarter. 2003. "400,000 Nematode ESTs on the Net," Trends in Parasitology , 19:283-286.
Scholl, E. H., J. L. Thorne, J. P. McCarter, D. M. Bird. 2003. "Horizontally Transferred Genes in Plant-parasitic Nematodes: A High-Throughput Genomic Approach," Genome Biology , 4:R39, 1-12.
McCarter, J. P., M. D. Mitreva, J. Martin, M. Dante, T. Wylie, U. Rao, D. Pape, Y. Bowers, B. Theising, C. Murphy, A. P. Kloek, B. Chiapelli, S. W. Clifton, D. M. Bird, and R. H. Waterston. 2003. "Analysis and Functional Classification of Transcripts from the Nematode Meloidogyne incognita ," Genome Biology , 4:R26,1-19.
McCarter, J. P., S. W. Clifton, D. M. Bird and R. H. Waterston. 2002. "Nematode Gene Sequences, Update for June 2002," Journal of Nematology , 34(2):71-74.
McCarter, J., P. Abad, J. T. Jones, and D. Bird. 2000. "Rapid Gene Discovery in Plant Parasitic Nematodes Via Expressed Sequence Tags," Nematology , 2(7):719-731.
Kliman, R. M., P. Andolfatto, J. A. Coyne, F. Depaulis, M. Kreitman, A. J. Berry, J. McCarter, J. Wakeley, J. Hey. 2000. "The Population Genetics of the Origin and Divergence of the Drosophila simulans Complex Species," Genetics , 156:1913-1931.
McCarter, J. P., D. McK. Bird, S. W. Clifton, and R. H. Waterston. 2000. "Nematode Gene Sequences, Update for December 2000," Journal of Nematology , 32(4):331-333.
McCarter, J., B. Bartlett, T. Dang, and T. Schedl. 1999. "On the Control of Oocyte Meiotic Maturation and Ovulation in C. elegans ," Developmental Biology , 205:111-128.
McCarter, J., B. Bartlett, T. Dang, and T. Schedl. 1997. "Soma / Germ Cell Interactions in C. elegans ; Multiple Events of Hermaphrodite Germline Development Require the Somatic Sheath and Spermathecal Lineages," Developmental Biology , 181:121-143.
McCarter, J. 1997. "The Regulation of Oocyte Maturation and Ovulation in Caenorhabditis elegans ," Washington University Ph.D. Thesis.
Iwasaki, K., J. McCarter, R. Francis and T. Schedl. 1996. " emo-1 , a Caenorhabditis elegans Sec61p gamma Homologue is Required for Oocyte Development and Ovulation," Journal of Cell Biology , 134:699-714. (joint 1 st author)
Kloek, A. P., J. P. McCarter, R. A. Setterquist, T. Schedl, D. E. Goldberg. 1996. " Caenorhabditis Globin Genes: Rapid Intronic Divergence Contrasts with Conservation of Silent Exonic Sites," Journal of Molecular Evolution , 43:101-108.
McCarter, J., M. Schreiber, R. Bhatnagar. 1993. "The Role of The Young Scientist Program at Washington University in the Science Education of Disadvantaged Students in St. Louis," Science , 259:1108. (Letter to the Editor)
McCarter, J., M. Shaw, L. Winer, G. Baumann. 1990. "The 20KD Variant of Human Growth Hormone Does Not Bind to Growth Hormone Receptors in Human Liver," Molecular and Cellular Endocrinology , 73:11-14.
McCarter, J. 1989. "Alcohol Dehydrogenase Duplication (Adh-Dup) Locus Nucleotide Polymorphism in Drosophila simulans ," Princeton University A.B. Thesis.
GENBANK SUBMISSIONS (Expressed Sequence Tags), Total of 256,669 Reported
Species Description Sequences Year
Ascaris suum large pig roundworm 29,962 2001-2003
Meloidogyne hapla root knot nematode 24,452 2002-2003
Heterodera glycines soybean cyst nematode 20,110 2000-2003
Meloidogyne incognita root knot nematode 19,000 2000-2003
Strongyloides ratti rat gut roundworm 14,761 2001-2004
Haemonchus contortus sheep barber pole worm 14,014 2002-2003
Meloidogyne chitwoodi root knot nematode 12,218 2002-2004
Pristionchus pacificus free-living nematode 12,172 1999-2002
Strongyloides stercoralis human gut roundworm 11,335 2000-2001
Ancylostoma ceylanicum human hookworm 10,590 2001-2003
Trichinella spiralis swine trichinosis nematode 10,548 2001-2003
Ancylostoma caninum dog hookworm 9,331 1999-2002
Xiphinema index dagger nematode 8,424 2004
Parastrongyloides trichosuri opossum gut roundworm 7,963 2001-2002
Meloidogyne javanica root knot nematode 7,565 2000-2004
Ostertagia ostertagi cattle brown stomach worm 6,558 2002
Globodera rostochiensis potato cyst nematode 5,040 2001
Meloidogyne arenaria root knot nematode 5,018 2001-2004
Toxocara canis large dog roundworm 4,370 2002
Dirofilaria immitis dog heartworm 4,005 2002
Brugia malayi human filarial worm 3,773 2002-2003
Trichuris vulpis dog whipworm 3,063 2003
Heterodera schachtii beet cyst nematode 2,662 2003
Globodera pallida potato cyst nematode 2,546 2004
Pratylenchus vulnus root lesion nematode 2,485 2004
Pratylenchus penetrans root lesion nematode 1,928 2002
Radopholus similis burrowing nematode 1,154 2004
Zeldia punctata free-living nematode 391 2000-2001
SELECTED PUBLIC PRESENTATIONS
"Genomic Approaches to Macrofilaricide Development," Invited Speaker, Macrofilaricide Review Meeting, Bill and Melinda Gates Foundation, Seattle, Washington, September, 2004.
McCarter, J. P., D. J. Williams, A. P. Kloek, M. C. Hresko, and B. J. Shortt. "Novel Nematicidal Chemistries Identified Through a Comparative and Functional Genomics Platform," Society of Nematology 43 rd Annual Meeting, Estes Park, CO, August, 2004.
McCarter, J., M. Mitreva, S. Clifton, J. Spieth, R. Wilson, R. Waterston. "Update on Nematode Genomics at Washington University's Genome Sequencing Center," Society of Nematology 43 rd Annual Meeting, Estes Park, CO, August, 2004.
"Identification and Validation of New Anti-Nematode Drugs," Invited Speaker, Filariasis Research Summit, Philadelphia, Pennsylvania, December, 2003.
"RNAi as a Functional Genomics Tool in the Discovery of Novel Anthelmintics and Nematicides," Invited Speaker, World Health Organization, Switzerland, October, 2003.
"Genome Based Approaches to the Discovery of Novel Anthelmintics and Nematicides," Invited Speaker, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, April, 2003.
"Genome Based Approaches to the Discovery of Novel Anthelmintics and Nematicides- Utilizing Hookworm and Strongyloides Expressed Sequence Tags," Annual Meeting of the American Society for Tropical Medicine and Hygiene, Denver CO, November, 2002.
"Lessons Learned from the Sequencing of Nematodes: Root Knot Nematode," Conference on Genomic Analysis of Plant-Associated Microbes, American Phytopathological Society, Washington DC, April, 2002.
"Genome Based Approaches to the Discovery of Novel Anthelmintics and Nematicides," Invited Speaker, Department of Microbiology, George Washington University, Washington DC, April, 2002.
"Genome Based Approaches to the Discovery of Novel Anthelmintics and Nematicides," Invited Speaker, Parasitology Seminar, Department of Molecular Microbiology, Washington University, February 2002.
"High Throughput Gene Discovery in Parasitic Nematodes by an EST Approach, Whitney Foundation Annual Meeting, New York, December, 2001.
McCarter, J., Bird, D., Clifton, S., Waterston, R., and the GSC EST Lab Group. "Results from High Throughput Gene Discovery in Parasitic Nematodes," Invited Speaker, Joint Meeting for the American Phytopathological Society and Society of Nematology, Salt Lake City, UT, August 2001. Phytopathology 91:S159.
"High Throughput Gene Discovery in Parasitic Nematodes; Results from an Initial 30,000 ESTs," Invited Speaker, Merial / American Association of Veterinary Parasitology Symposium, AAVP Annual Meeting, Boston, MA, July 2001.
McCarter, J., Clifton, S., Chiapelli, B., Pape, D., Martin, J., Wylie, T., Dante, M., Waterston, R. "Genes from Other Nematodes: A Progress Report on the GSC Parasitic Nematode EST Project," 13 th Biennial International C. elegans Conference, Los Angeles, CA, June 2001.
"Genes from Other Nematodes: A Progress Report on the GSC Parasitic Nematode EST Project," Invited Speaker, Syngenta Crop Protection, Research Triangle Park, NC, May 2001.
"Genes from Other Nematodes: A Progress Report on the GSC Parasitic Nematode EST Project," Invited Speaker, Department of Plant Pathology, North Carolina State University, Raleigh, NC, April 2001.
"High Throughput Gene Discovery in Parasitic Nematodes; Results from an Initial 30,000 ESTs," Invited Speaker, Parasitology Seminar, Department of Molecular Microbiology, Washington University, February 2001.
"High Throughput Gene Discovery in Parasitic Nematodes; Results from Meloidogyne, Ancylostoma, and Strongyloides ESTs," Molecular Helminthology Keystone Meeting, Taos, NM, January 2001.
"Parasite EST Projects: Current Status," Invited Speaker, Department of Agronomy, University of Missouri, Columbia, November 2000.
McCarter, J., D. Bird, U. Rao, A. Kloek, S. Clifton, D. Pape, J. Martin, T. Wylie, S. Eddy, R. Waterston, and the Washington University GSC EST Team. "Progress Toward High Throughput Gene Discovery in Parasitic Nematodes; Initial Findings from Meloidogyne incognita EST Sequencing," Society of Nematology Annual Meeting, Quebec City, Quebec Canada, June 2000.
McCarter, J., B. Bartlett, T. Dang, T. Schedl. "Regulation of Oocyte Maturation and Ovulation," International Caenorhabditis elegans Meeting, Madison, Wisconsin, May 1997.
"The Regulation of Meiotic Maturation and Ovulation in Caenorhabditis elegans ," Cal Tech Department of Biology, Pasadena, California, September 1996.
McCarter, J., B. Bartlett, T. Dang, T. Schedl. "Regulation of Meiotic Maturation and Ovulation in C. elegans," Midwest Caenorhabditis elegans Meeting, Normal, Illinois, June 1996.
"Oocyte Cell Cycle Arrest in C. elegans ," The Wellcome Trust Institute of Cancer and Developmental Biology, Cambridge University, Cambridge, England, U.K., and The Medical Research Council of Britain, Cambridge, England, U.K., August 1994.
McCarter, J. and T. Schedl. "Somatic Regulation of Germ line Development in C. elegans : Mitotic Proliferation, Germ Cell Sex Determination, and Oocyte Meiotic Arrest," Midwest Caenorhabditis elegans Meeting, Bloomington, Indiana, June 1994.
SELECTED POSTERS & ABSTRACTS
Mitreva, M., D. P. Jasmer, J. Appleton, J. Martin, M. Dante, T. Wylie, S. W. Clifton, R. H. Waterston, and J. P. McCarter. "Discovery of Candidate Developmentally Expressed Genes in Trichinella spiralis ," XIth International Conference on Trichinellosis, San Diego, CA, August, 2004.
Scholl, E. H., J. L. Thorne, J. P. McCarter, D. McK. Bird. "Horizontal Gene Transfer in Meloidogyne : A Computational Approach," Society of Nematology 43 rd Annual Meeting, Estes Park, CO, August, 2004.
Hresko, M. C., M. B. McLaird, J. D. Bradley, D. J. Williams, A. P. Kloek, W. N. Grant, R. Rao, G. Weil, and J. P. McCarter. "Discovery Pipeline for Anthelmintics with Novel Modes of Action," Joint Meeting of the American Association of Veterinary Parasitologists and the American Society of Parasitologists, Philadelphia, PA, July, 2004.
Mitreva, M., J. C. Martin, T. N. Wylie, M. Dante, S. W. Clifton, D. McK. Bird, R. Wilson, and J. P. McCarter. "Discovery of Candidate Developmentally Expressed Genes in Plant Parasitic Nematodes," European Society of Nematologists 27 th International Symposium, Rome, Italy, June, 2004.
Roze, E., M. Mitreva, J. McCarter, B. Stojanova, H. Overmars, J. Bakker, and G. Smant. "The Repertoire of Cell Wall Modifying Proteins of the Root-knot Nematode Meloidogyne chitwoodi ," European Society of Nematologists 27 th International Symposium, Rome, Italy, June, 2004.
Mitreva, M., J. P. McCater, J. Martin, C. Murphy, S. Clifton, and R. H. Waterston. "Comparative Genomics of Gene Expression in Parasitic and Free-living Nematodes," Society of Nematology Annual Meeting, Ithaca, New York, July, 2003.
Dautova, M., J. P. McCarter, S. W. Clifton, C. Murphy, J. C. Martin, T. N. Wylie, M. Dante, D. Pape, R. H. Waterston. "Revealing Genes Expressed in Parasitic Nematodes by Single Pass cDNA Sequencing," Plant and Animal Genome XI, San Diego, CA, January, 2003.
Bird, D., C. Opperman, J. Thorne, R. Schaffer, J. Kieber, S. Clifton, J. McCarter, T. Kepler. "Genomic Dissection of a Nematode-plant Interaction: a Tool to Study Plant Biology," National Science Foundation Plant Genome Meeting, Washington DC, September, 2002.
Zarlenga, D. S., M. Morimoto, J. F. Urban Jr., J. P. McCarter. "A TGF-Beta Homologue within Populations of Ascaris suum 4 th Stage Larvae (L4): Evidence for Multiple Splicing and Regulated Transcription between L4 in the Jejunum and Ileum Following Spontaneous Cure," 47 th Annual Meeting of the American Association of Veterinary Parasitologists, Nashville, TN, July 2002.
Dante, M., J. Martin, T. Wylie, J. McCarter, S. Clifton. "Clustering Parasitic Nematode ESTs Using Phrap/Consed," Midwest C. elegans Meeting, St. Louis, MO, June 2002.
Dante, M., J. Martin, T. Wylie, J. McCarter, S. Clifton. "Clustering Parasitic Nematode ESTs Using Phrap/Consed," Conference on Genome Sequencing and Biology, Cold Spring Harbor, NY, May 2002.
Thompson, F. J., C. P. Wilkes, C. Murphy, B. Chiapelli, J. McCarter, S. Clifton, M. E. Viney. "Genome analysis of the effect of the host immune response on Strongyloides ratti ," European Worm Meeting, 2002.
Wylie, T., J. McCarter, J. Martin, S. Clifton, R. Waterston. "Nematode.net, a Tool for Navigating Sequences from Parasitic and Free-living Nematodes," 13 th Biennial International C. elegans Conference, Los Angeles, CA, June 2001.
Bird, D., H. Koltai, J. Schaff, M. Dahn, C. Opperman, J. McCarter, S. Clifton, R. Waterston. "Genetics, Genomics and Cell Biology of Nematode Parasitism; the Power of Plants as Tractable Models," Molecular Helminthology Keystone Meeting, Taos, NM, January 2001.
McCarter, J., D. Bird, J. Hawdon, T. Nutman, S. Clifton, R. Waterston, and the GSC EST Lab Group. "High Throughput Gene Discovery in Parasitic Nematodes; Results from Meloidogyne, Ancylostoma, and Strongyloides ESTs," Molecular Helminthology Keystone Meeting, Taos, NM, January 2001.
McCarter, J. "Progress in High Throughput Gene Discovery from Parasitic Nematodes," The Helen Hay Whitney Foundation 43 rd Annual Meeting, Harriman, New York, December 2000.
McCarter, J., S. Clifton, R. Waterston, and the GSC EST Lab Group. "Nematode Gene Sequences Beyond C. elegans: An Update," The Worm Breeder's Gazette, 16:4, 16-17, September 2000.
Dang, T., J. McCarter, MT. Le, R. Francis, T. Schedl. "Isolation and Classification of C. elegans Mutants with the Endomitotic Oocytes (Emo) Phenotype," Midwest C. elegans Meeting, Normal, Illinois, June 1996.
Bartlett, B., J. McCarter, T. Schedl. "Germline Regulation of Sheath Contractile Activity During the C. elegans Ovulation Motor Program," Midwest Caenorhabditis elegans Meeting, Normal, Illinois, June 1996.
McCarter, J., B. Bartlett, T. Dang, T. Schedl. "The Regulation of Meiotic Maturation and Ovulation in Caenorhabditis elegans ," Molecular Helminthology Keystone Meeting, Santa Fe, NM, February 1996.
McCarter, J., B. Bartlett, T. Dang, T. Schedl. "Germ Cells May Modulate the Smooth Muscle Activity of the Somatic Gonad for Ovulation in C. elegans ," The Worm Breeder's Gazette, 14:2, 52-53, February 1996.
McCarter, J., B. Bartlett, T. Dang, S. Weiss, T. Schedl. "Time Course of Oocyte Development, Maturation, and Ovulation," The Worm Breeder's Gazette, 14:1, 68-69, October 1995.
McCarter, J., K. Iwasaki, T. Dang, MT. Le, R. Francis, and T. Schedl. "Endomitotic Oocytes in the C. elegans Gonad Can Result From the Loss of Meiotic Cell Cycle Arrest or Defective Ovulation," International Caenorhabditis elegans Meeting, Madison, Wisconsin, June 1995.
McCarter, J., B. Bartlett, S. Weiss, and T. Schedl. "Germline Feminization Suppresses the Gonad Sheath Activity Necessary for Ovulation in C. elegans," International Caenorhabditis elegans Meeting, Madison, Wisconsin, June 1995.
McCarter, J. and T. Schedl. "Somatic Regulation of Germline Development," The Worm Breeder's Gazette, 13:3, 40-43, June 1994.
McCarter, J., R. Francis, MT. Le, L. Wilson-Berry, T. Schedl. "Mutations Affecting the Somatic Gonad in C. elegans," International Caenorhabditis elegans Meeting, Madison, Wisconsin, June 1993.
CONTRIBUTIONS TO FUNDED PROJECT GRANT PROPOSALS
National Institutes of Health Phase I SBIR, P.I. James McCarter, Divergence, 2004
National Science Foundation Phase I SBIR, P.I. Michelle Hresko, Divergence, 2004
United States Department of Agriculture Phase I SBIR, P.I. Michelle Hresko, Divergence, 2004
United States Department of Agriculture Phase I SBIR, P.I. Barry Shortt, Divergence, 2004
National Institutes of Health Research Proposal, P.I. Richard Wilson, Washington Univ., 2004
National Science Foundation Phase II SBIR, P.I. Michelle Hresko, Divergence, 2003
National Institutes of Health Phase II SBIR, P.I. Andrew Kloek, Divergence, 2002
National Science Foundation Phase I SBIR, P.I. Michelle Hresko, Divergence, 2002
National Institutes of Health Phase I SBIR, P.I. Andrew Kloek, Divergence, 2001
National Science Foundation Research Proposal, P.I. David Bird, Washington Univ., 2000
National Institutes of Health Research Proposal, P.I. Robert Waterston, Washington Univ., 1999
National Science Foundation Research Proposal, P.I. Tim Schedl, Washington Univ., 1994
Howard Hughes Medical Institute Educational Grant, P.I. Bruce Dowton, Washington Univ., 1993
PROFESSIONAL SERVICE AND ORGANIZATIONS
World Health Organization / Tropical Disease Research Whitepaper Group on RNAi and Drug Discovery
Society of Nematology, Whitepaper Committee on Genomics
Helminth Genome Consortium, Whitepaper Group
WormBase, Associates Panel, www.wormbase.org
Peer Reviewer for: Science, Proceedings of the National Academy of Science, Trends in Parasitology, Journal of Parasitology, Gene, Journal of Molecular Evolution, Genes and Development, Molecular Biology of the Cell
Member of: American Association for the Advancement of Science, American Association of Veterinary Parasitologists, American Society of Parasitologists, American Society of Tropical Medicine and Hygiene, Biotechnology Industry Organization, and Society of Nematology
ACADEMIC SEQUENCING COLLABORATORS, PROJECTS
Judith Appleton, Cornell University, Trichinella spiralis
Prema Arasu, N. Carolina State Univ., Ancylostoma caninum, Toxocara canis, and Dirofilaria immitis
Thomas Baum, Iowa State Univ., Heterodera glycines
David Bird, N. Carolina State Univ., Meloidogyne incognita, M. javanica, and M. arenaria
Mark Blaxter, University of Edinburgh, Coordination of GSC and Sanger Centre Parasitic EST Projects
Richard Davis, City University of New York, Ascaris suum
Rick Davis, North Carolina State University, Heterodera glycines
Louis Gasbarre, USDA, Beltsville Station, Ostertagia ostertagi
Tim Geary, Pharmacia Corporation, Ascaris suum
Godelieve Gheysen, Ghent University, Heterodera schachtii
Warwick Grant and Chuck Shoemaker, Ag Research Inc, New Zealand, Parastrongyloides trichosuri
John Hawdon and Peter Hotez, George Washington Univ., Ancylostoma caninum, and A. ceylanicum
Doug Jasmer, Washington State Univ., Trichinella spiralis
Vadim Kapulkin, Univ. of Colorado, Ancylostoma ceylanicum
Andrew Kloek, Divergence Inc., Meloidogyne incognita, M. javanica, and Zeldia punctata
Thomas Nutman, NIH-NIAID, Strongyloides stercoralis
Charlie Opperman, N. Carolina State Univ., Heterodera glycines
Alan Scott, Johns Hopkins Univ., Ascaris suum
Geert Smant, Wageningen Univ., Globodera rostochiensis
Ralf Sommer, Max Plank Institute, Germany, Pristionchus pacificus
Paul Sternberg, Caltech, Incorporation of Parasite ESTs into C. elegans ACEDB
Gary Weil, Washington Univ., Brugia malayi
Valerie Williamson, University of California at Davis, Meloidogyne hapla
Mark Viney, Univ. of Bristol, U.K., Strongyloides ratti
Dante Zarlenga, USDA, Beltsville Station, Ascaris suum
COMMUNITY SERVICE
Founder, The Young Scientist Program , and Co-Founder, The Mad Scientist Network , St. Louis,
Program Leader ('91 - '93), Tutor ('93), Mentor ('95 - '97), Genetics Team Leader ('93 - '96),
Community Advisory Board Member (2001 - present).
YSP is a graduate student run collaboration between Washington University and the St. Louis City Public Schools for the improvement of science education in disadvantaged communities, including classroom teaching (500 students/year) and summer internships (12 students/year). With over 40 million page views annually, YSP's highly acclaimed Mad Scientist Network (www.madsci.org) is the largest non-profit science question and answer service on the Internet.
Reading Tutor; YMCA Literacy Program, St. Louis, 1990 - '92
WEB SITES
Divergence Inc. www.divergence.com
Parasitic Nematode Genomics www.nematode.net
The Genome Sequencing Center http:/ / genome.wustl.edu
The Young Scientist Program http://medicine.w u stl.edu/~ysp/
The Mad Scientist Network ww w .madsci.org
