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Explore our new Nematode Tissue Transcriptomes section!

NemaPath has been updated and expanded!

The genome of the human, blood-feeding hookworm Necator americanus has been decoded!

The NemaGene database is being updated and expanded!

NemaBrowse updated with new species!

Agriculture and Food Research Initiative (AFRI) grant awarded for a study aimed at Identifying and Characterizing Parasitic Nematode Vaccine Targets

News & Announcements January 2014

General News
Nematode Tissue Transcriptomes section now open!

Explore tissue-specific collections of genes in our new Nematode Tissue Transcriptomes section. This analysis repository hosts a number of projects with the goal of obtaining fundamental information about the biology of diverse cell types and potential interactions among tissues within nematodes.

The genome of the human, blood-feeding hookworm Necator americanus has been decoded!

In research funded by the National Institute of Health (NIH), the Australian Research Council and the National Health and Medical Research Council, the genome of Necator americanus, a blood-feeding human hookworm, has been decoded and is being published in Nature Genetics. See the press release here.

Grant awarded to Identify and Characterize Parasitic Nematode Vaccine Targets

The Agriculture and Food Research Initiative (AFRI) at the National Institute of Food and Agriculture (NIFA) awarded a grant enabling work aimed at Identifying and Characterizing Parasitic Nematode Vaccine Targets. Read all about it here.

New funding from the Bill & Melinda Gates Foundation supports the
development of new diagnostic tests for River blindness

Washington university scientists receive nearly million from the Bill & Melinda Gates foundation to develop new tests for "river blindness", a neglected tropical disease. Read all about it here.

Symposium Announcment
Anthelmintics: From Discovery to Resistance!

This symposium in San Francisco, California will be held Feburary 5th - 8th, 2014. Abstracts are invited for poster or oral presentations; the deadline for submission is November 15, 2013. Please visit www.ucs.iastate.edu/mnet/membrane/home.html for more details.

Genomics Empower Research on Neglected Tropical Diseases

This featured article highlights the current work of Makedonka Mitreva and her lab. link

New Data & Tools
NemaPath has been updated and expanded!

The NemaPath resource has been updated. The species based views have been updated with mappings to the genes database from KEGG release 68.0. New species have also been added into the viewer. We're still working on the clade, host & stage specific views, but the updated species views are now live. To explore NemaPath follow this link.

The NemaGene database is being updated and expanded!

The NemaGene database of genes and transcripts is being expanded to include many new worm species, and is being updated with new annotation! The update is happening now, but the service is available during the update. The database is now searchable using IPR id, GO term and/or KO id. Full database slices can now be downloaded as either protein sequence or nucleotide sequence, and the final annotation page for each gene provides a link that will push the sequence into our NemaBLAST service. Check it out here.

NemaBrowse updated with new species!

Seven new species now have gene annotations available in NemaBrowse! Check it out here.

Ascaris suum microarray data mirror now available! - Ascaris suum microarray data released by us in NCBI GEO as GSE36690 is now mirrored locally!

NemaGene Gene Tables - An online resource hosting available annotation for final genesets.

Next-gen transcript assembly data available - A resource allowing the user to download recent, 454-based, transcript assembly data. Nucleotide & translated protein fasta files for isotig consensus, isogroup membership and isotig membership files are all available for download, along with statistics about the assembly itself.

Publications within the last 6 months

Taylor CM, Martin J, Rao RU, Powell K, Abubucker S, Mitreva M. (2013) Using existing drugs as leads for broad spectrum anthelmintics targeting protein kinases. PLoS Pathog. Feb;9(2):e1003149. doi: 10.1371/journal.ppat.1003149. Epub 2013 Feb 14. link

Heizer E, Zarlenga DS, Rosa B, Gao X, Gasser RB, De Graef J, Geldhof P, Mitreva M. (2013) Transcriptome analyses reveal protein and domain families that delineate stage-related development in the economically important parasitic nematodes, Ostertagia ostertagi and Cooperia oncophora. BMC Genomics. Feb 22;14(1):118. [Epub ahead of print] link

Menon R, Gasser RB, Mitreva M, Ranganathan S. (2013) An analysis of the transcriptome of Teladorsagia circumcincta: its biological and biotechnological implications BMC Genomics Suppl 7:S10. doi: 10.1186/1471-2164-13-S7-S10. Epub 2012 Dec 13. link

DE Graef J, Demeler J, Skuce P, Mitreva M, VON Samson-Himmelstjerna G, Vercruysse J, Claerebout E, Geldhof P. (2013) Gene expression analysis of ABC transporters in a resistant Cooperia oncophora isolate following in vivo and in vitro exposure to macrocyclic lactones. Parasitology Apr;140(4):499-508. doi: 10.1017/S0031182012001849. Epub 2013 Jan 2. link

Pavan MG, Mesquita RD, Lawrence GG, Lazoski C, Dotson EM, Abubucker S, Mitreva M, Randall-Maher J, Monteiro FA. (2013) A nuclear single-nucleotide polymorphism (SNP) potentially useful for the separation of Rhodnius prolixus from members of the Rhodnius robustus cryptic species complex (Hemiptera: Reduviidae). Infect Genet Evol. Mar;14:426-33. doi: 10.1016/j.meegid.2012.10.018. Epub 2012 Dec 6. link

McNulty SN, Mitreva M, Weil GJ, Fischer PU. (2013) Inter and intra-specific diversity of parasites that cause lymphatic filariasis. Infect Genet Evol. Mar;14:137-46. doi: 10.1016/j.meegid.2012.11.002. Epub 2012 Nov 29. link

Wang J, Mitreva M, Berriman M, Thorne A, Magrini V, Koutsovouls G, Kumar S, Blaxter ML, Davis RE. (2012) Silencing of Germline-Expressed Genes by DNA Elimination in Somatic Cells. Developmental Cell 01 November 2012 doi:10.1016/j.devcel.2012.09.020 (link)

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